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RNDr. Alena Krejčí, Ph.D.

head of the Laboratory of Bee Biology

Faculty of Science, University of South Bohemia
Branišovská 31, 37005 České Budějovice
building B, ground floor, door number 192
 
Email: This email address is being protected from spambots. You need JavaScript enabled to view it.
Tel. +420 387772270
ORCID ID: 0000-0001-7589-4035 


RNDr. Alena Krejčí, Ph.D.

Current possitions

since 2019
Group leader

Laboratory of Bee Biology, Faculty of Science, University of South Bohemia

Previous possitions

2010-2019
Group leader

Laboratory of developmental biology, Faculty of Science, University of South Bohemia

2004-2010
Senior Research Associate

Department of Physiology, Development and Neuroscience, University of Cambridge, United Kingdom, Laboratory of Prof. Sarah Bray

2001-2004
Royal Society fellowship

University of Leeds, School of Biochemistry and Molecular Biology, United Kingdom. Laboratory of Prof. Noel Buckley.

1998-2004
Graduate and Ph. D. studies

Department of Neurochemistry, Institute of Physiology, Academy of Sciences, Prague. Laboratory of Prof. Stanislav Tucek and Dr. Vladimir Dolezal.

Education

2004
PhD in molecular genetics

Faculty of Science, Charles University, Prague

Awards and fellowships

2011
Early Research Career Award

British Biochemical Society 

Award for the best popular science article

Magazine 'Ziva' (in Czech, artical about the Warburg effect)

Winner of the L'Oreal Women in Science award
2005-2007
EMBO long term fellowship

University of Cambridge, UK, laboratory of prof. Sarah Bray

10 months in total between 2001–2004
Royal Society fellowship

School of Biochemistry and Molecular Biology, University of Leeds, UK, Laboratory of Prof. Noel Buckley

Grants

2019-2022
Nutritional supplement for bees with antiviral properties

Grant from the Technology Agency of Czech Republic

2017-2019
Metabolic stress as regulator of Notch signalling.

Grant from the Czech Grant Agency

2014-2016
The role of sirtuins in Notch signalling

Grant from the Czech Grant Agency

2011-2013
Signallization through the Notch receptor in the context of cellular metabolism.

Grant from the Czech Grant Agency

2011-2016
The interplay between Notch signalling and cellular metabolism

EMBO installation grant, Funding of 250k euro total.

Bee keeping experience

  • Active member of the local branch of the Czech beekeeping society and a hobby beekeeper (15 hives)
  • Co-manager of Experimental and educational apiary at the Biology Centre, Ceské Budějovice (30 hives)
  • Popular bee science talks to students and public
  • TV and radio programmes about bees, newspaper interviews
  • Current grant from the Technology Agency of the Czech Republic for antiviral effects of natural ingredience in bee keeping
  • Collaboration with the Department of robotics and embeded systems at the University of south Bohemia - designing a beehive themperature and CO2 sensors, image analysis using neural networks and machine learning

Mentoring

  • Mentor of 2 succesfully defended PhD students (plus 1 writing), 4 master students and 14 bachelor students.

Teaching

  • Molecular biology course (undegrad)
  • Developmental bIology course (undergrad)

Publications

  • Bruce Krejčí A, Krištůfek V: Mravenčí trápení (Tha ant's sorrow). Moderní včelař (Modern Beekeeper) 03, 34-35, 2022.
  • Bruce Krejčí A, Svobodová K, Krištůfek V: Testování kvality vosku stanovením jeho teploty tuhnutí (Testing the wax quality by assesing its setting temperature). Moderní včelař (Modern Beekeeper) 02, 16-18, 2022.
  • Krištůfek V, Bruce Krejčí A, Svobodová K, Chalupský J: Snižují houby virózy a úmrtnost včel? (Do mushrooms lower virus loads and mortality of honey bee colonies?)  Moderní včelař (Modern Beekeeper) 06, 28-30, 2021.
  • Urajová P., Krištůfek V., Bruce Krejčí A: Kyselina para-kumarová a výživa včel (Para-coumaric acid and bee nutrition). Moderní včelař (Modern Beekeeper) 07, 28-30, 2020.
  • Perez-Gomez R, Perez-Gomez R, Magnin V, Mihajlovic Z, Slaninova V and Krejci A: Downregulation of respiratory complex I mediates major signalling changes triggered by TOR activation. Scientific Reports 10, 4401, 2020.
  • Mihajlovic Z, Tanasic D, Bajgar A, Perez-Gomez R, Steffal P, Krejci A: Lime is a new protein linking immunity and metabolism in Drosophila. Developmental Biology 452(2):83-94, 2019.
  • Krejci A, Tennessen JM.: Metabolism in time and space - exploring the frontier of developmental biology. Development 144(18):3193-3198, 2017.
  • Horvath M, Mihajlovic Z, Slaninova V, Perez-Gomez R, Moshkin Y, Krejci A: The silent information regulator 1 (Sirt1) is a positive regulator of the Notch pathway in Drosophila. Biochemical journal 473(22):4129-4143, 2016.
  • Slaninova V, Krafcikova M, Perez-Gomez R, Steffal P, Trantirek L, Bray SJ and Krejci A: Notch stimulates growth by direct regulation of genes involved in the control of glycolysis and the tricarboxylic acid cycle. Open Biology, 2016 Feb;6(2)., 2016. doi: 10.1098/rsob.150155.
  • Housden BE, Fu AQ, Krejci A, Bernard F, Fischer B, Tavare S, Russell S, Bray SJ: Transcriptional Dynamics Elicited by a Short Pulse of Notch Activation Involves Feed-Forward Regulation by E(spl)/Hes Genes. Plos Genetics, 9(1):e1003162, 2013.
  • Djiane A, Krejci A, Bernard F, Fexova S, Millen K, Bray SJ.: Dissecting the mechanisms of Notch induced hyperplasia.  EMBO Journal 32, 60 - 71, 2013. doi:
  • Endo K, Karim MR, Taniguchi H, Krejci A, Kinameri E, Siebert M, Ito K., BraySJ, Moore AW: Chromatin modification of Notch targets in olfactory receptor neuron diversification. Nature Neuroscience, 15(2):224-33, 2012. doi: 10.1038/nn.2998.
  • Terriente-Felix A, Li J, Collins S, Mulligan A, Reekie I, Bernard F, Krejci A,  Bray SJ: Notch co-operates with Lozenge/Runx to lock hemocytes into a differentiation programme. Development, 140(4):926-37, 2013. doi: 10.1242/dev.086785
  • Bernard F, Krejci A, Housden B, Adryan B, Bray SJ: Specificity of Notch pathway activation: twist controls the transcriptional output in adult muscle progenitors. Development, 137(16):2633-42, 2010. doi: 10.1242/dev.053181
  • Krejci A*, Bernard F*, Housden BE*, Collins S, Bray SJ.: Direct response to Notch activation: signaling crosstalk and incoherent logic. Science Signal.,2(55), 2009. doi:10.1126/scisignal.2000140
  • Narasimha M, Uv A, Krejci A, Brown NH, Bray SJ.: Grainy head promotes expression of septate junction proteins and influences epithelial morphogenesis. J Cell Sci. 2008. doi: 10.1242/jcs.019422
  • Goodfellow H*, Krejcí A*, Moshkin Y*, Verrijzer CP, Karch F, Bray SJ.: Gene-specific targeting of the histone chaperone asf1 to mediate silencing. Dev Cell.13(4):593-600, 2007.PMID: 17925233
  • Krejci A and Bray S: Notch activation stimulates transient and selective binding of Su(H)/CSL to target enhancers.  Genes Dev. 21(11):1322-7, 2007. PMID: 17545467
  • Bruce AW, Krejci A, Ooi L, Deuchars J, Wood IC, Dolezal V, Buckley NJ. :The transcriptional repressor REST is a critical regulator of the neurosecretory phenotype. J Neurochem. 98(6):1828-40, 2006. PMID: 16945103
  • Nagel AC, Krejci A, Tenin G, Bravo-Patino A, Bray S, Maier D, Preiss A. : Hairless-mediated repression of notch target genes requires the combined activity of Groucho and CtBP corepressors. Mol Cell  Biol. 25(23):10433-41, 2005. PMID: 16287856
  • Jakubik J, Krejci A, Dolezal V: Asparagine, valine, and threonine in the third extracellular loop of muscarinic receptor have essential roles in the positive cooperativity of strychnine-like allosteric modulators. J Pharmacol Exp Ther. 313(2):688-96, 2005.
  • Krejci A, Bruce AW, Tucek S, Dolezal V, Buckley NJ: Multiple promoters drive tissue specific expression of the human M2 muscarinic acetylcholine receptor gene. Neurochem. 91(1):88-98, 2004.
  • Tucek S, Krejci A, Lysikova M, Jakubik J, Dolezal V: Roles of external loops of muscarinic receptors in interactions between N-methylscopolamine and allosteric modulators. In Cholinergic mechanisms: Function and disfunction. Ed. I. Silman, 71-76, 2004.
  • Krejci A, Michal P, Jakubik J, Ricny J, Dolezal V: Regulation of signal transduction at M2 muscarinic receptor. Physiol. Res., 53, suppl.1:S131-40, 2004.
  • Krejci A, Tucek S: Quantitation of mRNAs for M1 to M5 subtypes of muscarinic receptors in rat heart and brain cortex. Mol Pharmacol.  61(6):1267-72, 2002.
  • Krejci A, Tucek S: Changes of cooperativity between N-methylscopolamine and allosteric modulator alcuronium and gallamine induced by mutations of external loops of muscarinic M3 receptors. Mol. Pharmacol. 60 : 761-767, 2001.

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